The U.S.
Food and Drug Administration has required Bristol-Myers Squibb Co.,
manufacturer of the antidepressant Serzone, to include a black box
warning label advising patients of the possibility of serious liver
damage and liver failure which can ultimately cause death. A "black
box" warning is the most serious warning the FDA issues regarding
the safety of a drug and is reserved for the most dangerous side
effects. Yellowing of the skin or the whites of the eyes (jaundice),
Unusually dark urine, Loss of appetite that lasts several days or
longer, Nausea, and abdominal pain are all symptoms of liver complications.
